Acinic cell carcinoma is a lowgrade neoplasm occurs on the epithelial cell lining of the salivary gland. Malignant epithelial neoplasm composed of cells with morphological resemblance to acinar cells and with evidence of pancreatic exocrine enzyme production iarc. Primary acinic cell carcinoma of the breast associated. Mar 30, 2012 strong staining can be used to support the diagnosis of acinic cell carcinoma. They are triplenegative breast cancers even if their biological behaviour seems to be more favourable. Acinar cell carcinoma of the pancreas stanford university. It is a lowgrade salivary neoplasm that constitutes about 5% to 17% of cases involving. An acinic cell carcinoma acc of salivary gland is a type of malignant epithelial tumor affecting either the major or minor salivary glands. Batsakis 8 has described a histological grading of acc, which identifies 3. Metastasis of acinic cell carcinoma of the parotid gland. Dog1 may also be a marker of a transformed myoepithelial phenotype in a subset of biphasic salivary gland.
Case report primary acinic cell carcinoma of the nasal septum. Third most common malignancy of major salivary gland 15%. Case report welldifferentiated acinic cell carcinoma with lymphoid. Answering questions about acc is apostolia tsimberidou, m. Relapsed acinic cell carcinoma of the parotid gland with. Two cases of mucoepidermoid carcinoma diagnosed in cytology were later confirmed by histopathology. Characteristically slow growing with clinical behavior reflective of a lowgrade tumor, although 25 50% of patients with acinic cell carcinoma can recur if not treated adequately. Jan 21, 2019 acinic cell carcinoma acicc is a rare salivary gland carcinoma that is poorly understood. Enhancer hijacking activates oncogenic transcription factor. Histopathologic grading of salivary gland neoplasms. Oct 27, 2019 acinic cell carcinoma acc is a special type of breast carcinoma showing serous differentiation, with zymogentype cytoplasmic granules, similar to acinic cell carcinoma arising in the parotid gland eusebi et al. Monotonous proliferation of cells with abundant finely granular, weakly eosinophilic or clear vacuolated cytoplasm, central round nuclei and prominent nucleoli, resembling acinic cells of salivary gland j clin pathol 2003. Youll hear about new websites, ipad apps, pathcasts, and other educational materials. Acinic cell carcinoma acc is a lowgrade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies.
Highgrade transformation dedifferentiation of acinic. Clear cells in acinic cell carcinoma of the salivary gland are thought to be caused by tissue processing artefact or changes in organelles, including dilated rough endoplasmic reticulum. I present with this, a case report where incidental results detected by histopathology examination with acinic cell carcinoma of the parotid gland which is a rare entity of parotid tumour. Most cases arise in the major glands, particularly the parotid. Case report primary acinic cell carcinoma of the breast.
Carcinoma of the pancreas exhibiting exocrine differentiation and lacking significant histopathology and histochemistry, and include this rare tumor in the differential diagnosis of feline nasal diseases. Immunohistochemical study of 30 cases using the mib 1 antibody in formalinfixed paraffin. Almost 17 percent of the primary salivary gland carcinoma is related to the acinic cell carcinoma. Pdf acinic cell carcinoma acc is a lowgrade malignant salivary neoplasm that. Trk antibody distinguishes secretory carcinoma of the salivary gland from acinic cell carcinoma. Amongst primary parotid gland malignancies, acinic cell carcinoma aicc. Fineneedle aspiration fna cytology is commonly used to evaluate salivary gland lesions and is considered to be highly accurate in the diagnosis of salivary gland tumors.
A usually slowgrowing malignant tumor that that can occur in various parts of the body but is most often found in the pancreas, salivary glands, palate and upper lip. Wed like to send you periodic updates regarding pathology educational materials released by our department. To the best of our knowledge, only 17 cases of acinic cell car. Metastasis of acinic cell carcinoma of the parotid gland to. When these tumors are welldifferentiated, the neoplasia has innocuous aspect, due to the similarity to normal parotid tissue. Predictors of distant metastasis in acinic cell carcinoma of the. Carcinoma of the pancreas exhibiting exocrine differentiation and lacking significant acinic cell carcinoma note that solidpseudopapillary neoplasm was erroneously considered in some early reports to be acinar and designated cystic acinar cell carcinoma diagnostic criteria. Pdf a rare case of acinic cell carcinoma of the palate find, read. Original article clinical characteristics, therapy and. Trk, though membranous expression of trk is common in other salivary gland. Acinic cell carcinoma acc of the parotid is a rare tumor and therefore information compared to other tumor types is relatively limited.
Pathology pathology may superficially resemble normal serous acinar cells of the salivary glands. It was initially thought to be benign disease entity and foote and frazell 1,2 first coined it as a carcinoma in the early 1950s. Acinic cell carcinoma of the parotid gland with four. Acinic cell carcinoma of the breast arising in microglandular. Acinic cell carcinoma johns hopkins surgical pathology. Mar 10, 2016 i present with this, a case report where incidental results detected by histopathology examination with acinic cell carcinoma of the parotid gland which is a rare entity of parotid tumour. Acinic cell carcinoma accc is a malignant epithelial salivary gland neoplasm that demonstrates serous acinar cell differentiation with cytoplasmic zymogen. Sep 27, 2018 acinic cell carcinoma acc of the breast is extremely rare subtype of triplenegative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. Damiani s, pasquinelli g, lamovec j, peterse jl, eusebi v. Acinic cell carcinoma causes, treatment, prognosis. Acinic cell carcinoma arising in salivary glands is a rare tumor, accounting for 2%. Acinic cell carcinoma genetic and rare diseases information.
Relapsed acinic cell carcinoma of the parotid gland with diffuse distant metastasis. Seventeen percent arise in the intraoral minor salivary glands buccal mucosa, upper lip. The majority arise in the parotid gland, most commonly in women. Acinic cell carcinoma is a rare breast tumour belonging to salivary glandlike tumours of the breast. It is characterized by a low and highgrade component juxtaposed with one another and tends to take on a more aggressive clinical course than its lowgrade counterpart, suggesting a poor clinical outcome. The chart showing pdf series, word series, html series, scan qr codes.
Acinic cell carcinoma is an uncommon salivary gland neoplasm that typically occurs in the parotid gland and is considered a lowgrade malignancy. Enhancer hijacking activates oncogenic transcription. Electron micrograph of tumor cell demonstrates numerous cytoplasmic granules of varying electron density consistent with zymogen granules. Acinic cell adenocarcinoma, a low grade malignant tumor, seen at any age but most prevalent in. At scanning power, basophillia and prominent lymphoid infiltrate should raise suspicion of acinic cell carcinoma tumor shows multidirectional differentiation towards acinar, ductal as well as myoepithelial elements some tumor cells must demonstrate differentiation towards acinar cells. Metastasis is unusual and, if present, predominantly involves the lung and bones. Acinic cell carcinoma accc of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation. Three cases of acinic cell carcinoma and one case of adenocarcinoma were also correctly diagnosed in fnac. Untreated accs usually present as solitary, encapsulated, soft tumors of a greywhite color figure 1. Intraductal and papillary variants of acinar cell carcinomas. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men.
Original article clinical characteristics, therapy and prognosis of parotid acinar cell carcinoma xilin nie 1, jialei gu, wendong wang 1, kejing wang, jinbiao shang1,2 1department of head and neck surgery, zhejiang cancer hospital, hangzhou, china. Veterinarians and veterinary pathologists should be aware of acinic cell carcinoma, which is readily distinguished from other neoplasms by histopathology and histochemistry, and include this rare tumor in the differential diagnosis of feline nasal diseases. Pdf nodal metastases in acinic cell carcinoma of the. Review and updates of immunohistochemistry in selected. Close margins and adjuvant radiotherapy in acinic cell.
Acinic cell carcinoma salivary glands radiology reference. Acinic cell carcinoma of minor salivary glands acinic cell carcinoma of minor salivary glands ferlito, a. We strongly recommend that you talk with a trusted healthcare. Acinic cell carcinoma acicc is a rare salivary gland carcinoma that is poorly understood. Herein, we report a case of acinic cell carcinoma of the breast in a 41year old female presenting with a palpable breast mass along with significant morphological and immunohistochemical findings. Acinic cell carcinoma acc of the breast is extremely rare subtype of triplenegative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. Highgrade transformation dedifferentiation of acinic cell. Primary acinic cell carcinoma of the breast journal of. Review and updates of immunohistochemistry in selected salivary. The disease presents as a slow growing mass, associated with pain or tenderness in 50% of the cases. Acinic cell carcinoma is a slowgrowing malignant tumor, normally developing in the parotid glands and the major and minor salivary glands, upper lip, buccal mucosa, and the palate. Acinic cell carcinoma arising in minor salivary gland of the upper lip. One case reported as poorly differentiated carcinoma in fnac turned out to be epithelial myoepithelial carcinoma. Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin.
Acinic cell carcinoma reported to be the second most common malignant tumor of the accessory parotid gland 12. A gradual mass progression of the terminal end of the parotid gland usually affected. Fine needle aspiration cytology of salivary gland lesions. Primary acinic cell carcinoma of the breast associated with. Acinic cell carcinoma, abbreviated accc, is a rare type of salivary gland cancer. More detailed information about the symptoms, causes, and treatments of acinic cell carcinoma is. We aimed to assess demographic, histopathologic and clinical. An end should be considered in patients with acinic cell carcinoma of the parotid gland due to i a notable rate of occult neck metastases in lowgrade tumors and ii the worse dss of patients. Acinic cell carcinoma is the second most common salivary gland malignancy, representing approximately 4% to 6% of all salivary gland neoplasms and up to 17% of malignancies. Aspirates from these tumors can be diagnostically challenging. Acinic cell carcinoma with highgrade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. Journal of oral and maxillofacial surgery, medicine, and pathology, vol. Histologically, acc showed a diffuse glandular infiltrative pattern, with small acinar or glandular structures mixed with solid nests. Acinic cell carcinoma an overview sciencedirect topics.
It is also known as acinic cell adenocarcinoma it should not to be confused with pancreatic acinar cell carcinoma. Update in salivary gland pathology arup laboratories. Dec 12, 2014 acinic cell carcinoma arising in salivary glands is a rare tumor, accounting for 2% to 5% of the primary neoplasms of the parotid gland. According to the world health organization, acinic cell carcinoma acc is a malignant epithelial neoplasm of the salivary glands in which at least some of the neoplastic cells demonstrate serous acinar cell differentiation characterized by cytoplasmic zymogen secretory granules. Pathology clinic salivary gland acinic cell carcinoma. Pdf acinic cell carcinoma of palate a rare presentation. Salivary gland carcinomas are rare malignant tumors with diverse histopathology. Here the authors perform genomic, transcriptomic and epigenomic profiling of acicc and find highly. Strong staining can be used to support the diagnosis of acinic cell carcinoma. Acinic cell carcinoma of the parotid gland with four morphological. Acinic cell carcinoma cytologic features and diagnostic. Acinic cell carcinoma symptoms, diagnosis, treatments and. Trk expression is not entirely sensitive or specific for secretory carcinoma, nuclear staining distinguishes secretory carcinoma from mimics.
Acinic cell carcinoma of the head and neck is an uncommon salivary gland cancer, with a reported incidence of less than 1 case per 100 000 population. Acinar cell carcinoma of pancreas surgical pathology. Herein, we report a case of acinic cell carcinoma of the breast in a yearold woman. It should not to be confused with pancreatic acinar cell carcinoma. Acinic cell carcinoma is a rare cancer of the salivary glands that originates from the parotid gland. Acinic cell carcinoma is an uncommon lowgrade malignant tumor of the salivary glands, in which some cells resemble normal acinic cells. Acinic cell carcinoma acc is an uncommon salivary gland neoplasm that generally displays an indolent growth pattern. Acinic cell carcinoma cytologic features and diagnostic pi. Acinic cell carcinoma acc is a special type of breast carcinoma showing serous differentiation, with zymogentype cytoplasmic granules, similar to acinic cell carcinoma arising in the parotid gland eusebi et al. The lesions that have to be considered in the differential. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. This type of neoplasm is commonly found in the parotid gland and has a diffuse infiltrative growth pattern, with small acinar or glandular structures composed of a monotonous proliferation of cells with. Acinic cell carcinoma is an uncommon malignant neoplasm, mostly arising in the parotid gland.
Basturk o, zamboni g, klimstra ds, capelli p, andea a, kamel ns, adsay nv. Acinic cell carcinoma arising in salivary glands is a rare tumor, accounting for 2% to 5% of the primary neoplasms of the parotid gland. Keywords acinic cell carcinoma 4 pathology 4 salivary glands 4 therapy 4 prognosis 4 mammary analog secretory carcinoma. Imaging findings in acinic cell carcinoma are nonspecific and there is an overlap with benign tumors such as warthin tumor and pleomorphic adenoma 6. Acinic cell carcinoma of the lung with metastasis to lymph. Acinic cell carcinoma is a lowgrade malignant neoplasm that constitutes approximately 17% of sgts and mostly develops in the parotid gland 80%. Department of pathology, university of arkansas for medical. Some tumor cells must demonstrate differentiation towards acinar cells variable patterns. Acinic cell carcinoma of the breast is an extremely rare, malign ant neoplasm characterized by widespread acinar celllike di erentiation and clinically lowgrade malignancy. Symptoms are determined by the size and location of the growth. Acinic cell carcinomas of the salivary glands are rare malignant neoplasms that account for % of all salivary gland tumors. Primary acinic cell carcinoma of the breast associated with an intraductal acinic cell component 4.
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